Ulyanovsk Medico-biological Journal

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DOI 10.34014/2227-1848-2025-2-6-18

ACUTE KIDNEY INJURY IN PATIENTS WITH MYOCARDIAL INFARCTION AND NEW CORONAVIRUS INFECTION (COVID-19)

A.Yu. Denisova1, M.V. Menzorov1, S.F. Kerimova2, M.V. Gorbunov1, V.M. Menzorov3, E.O. Bubas1

1 Ulyanovsk State University, Ulyanovsk, Russia;

2 Ulyanovsk Regional Clinical Hospital, Ulyanovsk, Russia;

3 Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia

 

Acute kidney injury is a common pathological condition that complicates various diseases and affects both the short-term and long-term prognosis. There is ample research which testifies the unfavorable prognostic role of acute kidney injury in patients with myocardial infarction. The problem of acute kidney injury has become especially relevant during the COVID-19 pandemic, periodic outbreaks of which associated with new virus mutation are still observed. COVID-19 can both destabilize the existing pathology and lead to the development of new diseases, including myocardial infarction. In patients with myocardial infarction and COVID-19, a multiplicative risk effect of getting acute kidney injury is expected, the mechanism of which is likely to be different in each particular case: COVID-19 can simultaneously lead to a combination of renal and cardiac complications; acute kidney injury can develop due to heart failure, direct heart injury or myocardial infarction regardless of the new coronavirus infection. The article reviews the studies on the correlation between creatinine levels, renal dysfunction and the risk of myocardial infarction in COVID-19 patients. The authors describe the pathophysiological basis of cardiorenal correlation in COVID-19, which is characterized by the complexity and uniqueness of changes.

Key words: acute kidney injury, acute coronary syndrome, myocardial infarction, COVID-19, new coronavirus infection.

 

Conflict of interest. The authors declare no conflict of interest.

Author contributions

Research concept and design: Menzorov M.V.

Literature search, participation in the study, data processing: Menzorov M.V., Denisova A.Yu., Kerimova S.F., Gorbunov M.V., Menzorov V.M., Bubas E.O.

Data analysis and interpretation: Menzorov M.V., Denisova A.Yu., Kerimova S.F., Gorbunov M.V., Menzorov V.M., Bubas E.O.

Text writing and editing: Menzorov M.V., Denisova A.Yu.

 

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Received January 16, 2025; accepted February 20, 2025.

 

Information about the authors

Denisova Anna Yur'evna, Postgraduate Student, Department of Therapy and Occupational Diseases, Ulyanovsk State University. 432017, Russia, Ulyanovsk, L. Tolstoy St., 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0000-0003-0974-5407

Menzorov Maksim Vital'evich, Doctor of Sciences (Medicine), Professor, Chair of Therapy and Occupational Diseases, Ulyanovsk State University. 432017, Russia, Ulyanovsk, L. Tolstoy St., 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0000-0002-6000-4850

Kerimova Sabina Faigovna, Cardiologist, Department of Cardiac Surgery and Heart Rhythm Disorders, Ulyanovsk Regional Clinical Hospital. 432017, Russia, Ulyanovsk, Tret'ego Internatsionala St., 7; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0009-0008-0005-4574

Gorbunov Maksim Vasil'evich, Candidate of Sciences (Medicine), Associate Professor, Chair of Public Health and Healthcare, Ulyanovsk State University. 432017, Russia, Ulyanovsk, L. Tolstoy St., 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0009-0009-7194-7350

Menzorov Viktor Maksimovich, Clinical Resident, Chair of Propaedeutic Therapy with a Course in Cardiology, Samara State Medical University, Ministry of Health of the Russian Federation. 443099, Russia, Samara, Chapaevskaya St., 89; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: https://orcid.org/0009-0007-2981-4699

Bubas Emma Olegovna, Student, Department of Medicine, Institute of Medicine, Ecology and Physical Education, Ulyanovsk State University. 432017, Russia, Ulyanovsk, L. Tolstoy St., 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: https://orcid.org/0009-0009-8636-6508

 

For citation

Denisova A.Yu., Menzorov M.V., Kerimova S.F., Gorbunov M.V., Menzorov V.M., Bubas E.O. Ostroe povrezhdenie pochek u patsientov s infarktom miokarda v sochetanii s novoy koronavirusnoy infektsiey (COVID-19) [Acute kidney injury in patients with myocardial infarction and new coronavirus infection (COVID-19)]. Ul'yanovskiy mediko-biologicheskiy zhurnal. 2025; 2: 6–18. DOI: 10.34014/2227-1848-2025-2-6-18 (in Russisn).

 

 

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УДК 616-06

DOI 10.34014/2227-1848-2025-2-6-18

ОСТРОЕ ПОВРЕЖДЕНИЕ ПОЧЕК У ПАЦИЕНТОВ С ИНФАРКТОМ МИОКАРДА В СОЧЕТАНИИ С НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИЕЙ (COVID-19)

А.Ю. Денисова1, М.В. Мензоров 2, С.Ф. Керимова 2, М.В. Горбунов 1, В.М. Мензоров 3, Э.О. Бубас 3

1 ФГБОУ ВО «Ульяновский государственный университет», г. Ульяновск, Россия;

2 ГУЗ Ульяновская областная клиническая больница, г. Ульяновск, Россия;

3 ФГБОУ ВО «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации, г. Самара, Россия

 

Острое повреждение почек является частым патологическим состоянием, осложняющим течение различных заболеваний и влияющим как на краткосрочный, так и на отдаленный прогноз. У пациентов с инфарктом миокарда неблагоприятная прогностическая роль острого повреждения почек продемонстрирована в значительном числе исследований. Особую актуальность проблема острого повреждения почек приобрела в эпоху пандемии новой коронавирусной инфекции (COVID-19), периодические вспышки которой отмечаются до сих пор, что связано с очередной мутацией вируса. COVID-19 способен как дестабилизировать течение имеющейся патологии, так и привести к возникновению новых заболеваний, в том числе инфаркта миокарда. У пациентов с инфарктом миокарда в сочетании с новой коронавирусной инфекцией ожидается мультипликативный эффект риска развития острого повреждения почек, механизм которого в каждом конкретном случае, вероятно, отличается: COVID-19 может одновременно вести к сочетанию почечных и кардиальных осложнений; острое повреждение почек может развиваться вследствие сердечной недостаточности, прямого повреждения сердца или инфаркта миокарда независимо от новой коронавирусной инфекции. В статье рассмотрены результаты исследований, касающихся взаимосвязи уровня креатинина, почечной дисфункции и риска развития инфаркта миокарда при новой коронавирусной инфекции. Описана патофизиологическая основа кардиоренальных взаимоотношений при COVID-19, характеризующаяся сложностью и уникальностью изменений.

Ключевые слова: острое повреждение почек, острый коронарный синдром, инфаркт миокарда, COVID-19, новая коронавирусная инфекция.

 

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Вклад авторов

Концепция и дизайн исследования: Мензоров М.В.

Литературный поиск, участие в исследовании, обработка материала: Мензоров М.В., Денисова А.Ю., Керимова С.Ф., Горбунов М.В., Мензоров В.М., Бубас Э.О.

Анализ и интерпретация данных: Мензоров М.В., Денисова А.Ю., Керимова С.Ф., Горбунов М.В., Мензоров В.М., Бубас Э.О.

Написание и редактирование текста: Мензоров М.В., Денисова А.Ю.

 

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Поступила в редакцию 16.01.2025; принята 20.02.2025.

 

Авторский коллектив

Денисова Анна Юрьевна – аспирант кафедры терапии и профессиональных болезней, ФГБОУ ВО «Ульяновский государственный университет». 432017, Россия, г. Ульяновск, ул. Л. Толстого, 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0000-0003-0974-5407

Мензоров Максим Витальевич – доктор медицинских наук, профессор кафедры терапии и профессиональных болезней, ФГБОУ ВО «Ульяновский государственный университет». 432017, Россия, г. Ульяновск, ул. Л. Толстого, 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0000-0002-6000-4850

Керимова Сабина Фаиговна – врач-кардиолог отделения кардиохирургии и нарушений ритма сердца, ГУЗ Ульяновская областная клиническая больница. 432017, Россия, г. Ульяновск, ул. Третьего Интернационала, 7; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0009-0008-0005-4574.

Горбунов Максим Васильевич – кандидат медицинских наук, доцент кафедры общественного здоровья и здравоохранения, ФГБОУ ВО «Ульяновский государственный университет». 432017, Россия, г. Ульяновск, ул. Л. Толстого, 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0009-0009-7194-7350

Мензоров Виктор Максимович – клинический ординатор кафедры пропедевтической терапии с курсом кардиологии, ФГБОУ ВО «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации. 443099, Россия, г. Самара, ул. Чапаевская, 89; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: https://orcid.org/0009-0007-2981-4699

Бубас Эмма Олеговна – студентка медицинского факультета Института медицины, экологии и физической культуры, ФГБОУ ВО «Ульяновский государственный университет». 432017, Россия, г. Ульяновск, ул. Л. Толстого, 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: https://orcid.org/0009-0009-8636-6508

 

Образец цитирования

Денисова А.Ю., Мензоров М.В., Керимова С.Ф., Горбунов М.В., Мензоров В.М., Бубас Э.О. Острое повреждение почек у пациентов с инфарктом миокарда в сочетании с новой коронавирусной инфекцией (COVID-19). Ульяновский медико-биологический журнал. 2025; 2: 6–18. DOI: 10.34014/2227-1848-2025-2-6-18.