Ulyanovsk Medico-biological Journal

CLINICAL MEDICINE

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DOI 10.34014/2227-1848-2021-2-83-96

CLINICAL CHARACTERISTICS, PROGNOSIS AND TREATMENT OF ANDROGEN-RECEPTOR-POSITIVE TRIPLE-NEGATIVE BREAST CANCER

I.S. Panchenko1, V.V. Rodionov2, S.V. Panchenko1, M.G. Sharafutdinov1

1 Ulyanovsk Syate University, Ulyanovsk, Russia;

2 National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia

 

This literature review focuses on the prognostic, clinical, and therapeutic characteristics of androgen receptor-positive triple-negative breast cancer.

Breast cancer (BC) is the most common malignant tumor among the female population. It accounts for about 21 % of all malignant neoplasms in Russia. The most unfavorable BC subtype is triple negative breast cancer (TNBC). TNBC is a subgroup of malignant breast tumors characterized by an aggressive progress and poor prognosis. It mostly affetcs young women. Despite the high sensitivity to neoadjuvant polychemotherapy, locoregional recurrence rate for TNBC is rarther high. Survival rate for patinets with TNBC is lower compared to patinets with other BC subtypes. Due to the widespread introduction of molecular genetic research methods into the algorithms for BC diagnosis, we can claim that TNBC is a heterogeneous group of tumors with different prognosis, clinical characteristics and response to therapy. Currently, drug therapy for TNBC is based solely on systemic chemotherapy. National treatment standards do not suggest any methods to treat this type of tumor. However, according to recent studies, antiandrogenic drugs can be successfully used in the TNBC therapy. The study of androgen receptor-positive triple-negative breast cancer seems promising for two reasons. The first reason is the availability of IHC diagnostics in most oncological centers in Russia. The second reason is the availability of relatively inexpensive endocrine therapy.

Keywords: breast cancer, triple negative breast cancer, androgen receptor positive triple negative breast cancer, androgen receptors, androgen receptor expression, antiandrogen therapy.

Conflict of interest. The authors declare no conflict of interest.

 

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Received 15 March 2021; accepted 24 May 2021.

 

Information about the authors

Panchenko Ivan Sergeevich, Post-graduate Student, Chair of Oncology and Radiation Diagnostics, Medical Department named after T.Z. Biktimirov, Ulyanovsk State University. 432017, Russia, Ulyanovsk, L. Tolstoy St., 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0000-0001-7923-4317

Rodionov Valeriy Vital'evich, Doctor of Sciences (Medicine), Head of the Department of Breast Pathology, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov, Ministry of Health of the Russian Federation. 117997, Russia, Moscow, Akademik Oparin St., 4; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0000-0003-0096-7126

Panchenko Sergey Viktorovich, Candidate of Sciences (Medicine), Associate Professor, Chair of Oncology and Radiation Diagnostics, Medical Department named after T.Z. Biktimirov, Ulyanovsk State University. 432017, Russia, Ulyanovsk, L. Tolstoy St., 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID: http://orcid.org/0000-0002-9006-2023

Sharafutdinov Marat Gakifovich, Candidate of Sciences (Medicine), Head of the Chair of Oncology and Radiation Diagnostics, Medical Department named after T.Z. Biktimirov, Ulyanovsk State University. 432017, Russia, Ulyanovsk, L. Tolstoy St., 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.; ORCID: http://orcid.org/0000-0002-8782-4111

 

For citation

Panchenko I.S., Rodionov V.V., Panchenko S.V., Sharafutdinov M.G. Osobennosti kliniki, prognoza i lecheniya androgen-retseptor-pozitivnogo trizhdy negativnogo raka molochnoy zhelezy [Clinical features, prognosis and treatment of androgen-receptor-positive triple-negative breast cancer]. Ul'yanovskiy mediko-biologicheskiy zhurnal. 2021; 2: 83–96. DOI: 10.34014/2227-1848-2021-2-83-96 (in Russian).

 

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DOI 10.34014/2227-1848-2021-2-83-96

ОСОБЕННОСТИ КЛИНИКИ, ПРОГНОЗА И ЛЕЧЕНИЯ АНДРОГЕН-РЕЦЕПТОР-ПОЗИТИВНОГО ТРИЖДЫ НЕГАТИВНОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ

И.С. Панченко1, В.В. Родионов2, С.В. Панченко1, М.Г. Шарафутдинов1

1 ФГБОУ ВО «Ульяновский государственный университет», г. Ульяновск, Россия;

2 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова» Министерства здравоохранения РФ, г. Москва, Россия

 

Данный литературный обзор посвящен рассмотрению прогностических, клинических и лечебных особенностей андроген-рецептор-позитивного трижды негативного рака молочной железы.

Рак молочной железы (РМЖ) – самая распространенная злокачественная опухоль среди женского населения, на ее долю приходится около 21 % всех случаев злокачественных новообразований в Российской Федерации. Наиболее неблагоприятным подтипом РМЖ является трижды негативный рак молочной железы (ТНРМЖ). ТНРМЖ – это подгруппа злокачественных опухолей молочной железы, характеризующихся агрессивным течением и неблагоприятным прогнозом, наиболее часто поражающих женщин молодого возраста. Несмотря на высокую чувствительность к неоадъювантной полиохимиотерапии, частота локорегионарного рецидива при ТНРМЖ остается высокой. Выживаемость при ТНРМЖ по сравнению с другими подтипами РМЖ ниже. Благодаря широкому внедрению молекулярно-генетических методов исследования в алгоритмы диагностики РМЖ можно утверждать, что ТНРМЖ – это гетерогенная группа опухолей с различным прогнозом, клиническими особенностями и ответом на лечение. В настоящее время лекарственная терапия ТНРМЖ опирается исключительно на системную химиотерапию, каких-либо мишеней для лечения этого вида опухолей в национальных стандартах не существует. Однако, согласно последним исследованиям, в терапии ТНРМЖ с успехом могут быть применены антиандрогенные препараты. Представляется перспективным изучение андроген-рецептор-позитивного трижды негативного рака молочной железы по двум причинам. Первая – возможность ИГХ-диагностики в большинстве онкологических центров РФ, вторая – возможность использования доступного и относительно недорого вида лечения – эндокринной терапии.

Ключевые слова: рак молочной железы, трижды негативный рак молочной железы, андроген-рецептор-позитивный трижды негативный рак молочной железы, андрогенные рецепторы, экспрессия андрогенных рецепторов, антиандрогенная терапия.

 

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Поступила в редакцию 15.03.2021; принята 24.05.2021.

 

Авторский коллектив

Панченко Иван Сергеевич – аспирант кафедры онкологии и лучевой диагностики медицинского факультета им. Т.З. Биктимирова, ФГБОУ ВО «Ульяновский государственный университет». 432017, Россия, г. Ульяновск, ул. Л. Толстого, 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0000-0001-7923-4317

Родионов Валерий Витальевич – доктор медицинских наук, заведующий отделением патологии молочной железы, ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова» Министерства здравоохранения РФ. 117997, Россия, г. Москва, ул. Академика Опарина, 4; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID ID: http://orcid.org/0000-0003-0096-7126

Панченко Сергей Викторович – кандидат медицинских наук, доцент кафедры онкологии и лучевой диагностики медицинского факультета им. Т.З. Биктимирова, ФГБОУ ВО «Ульяновский государственный университет». 432017, Россия, г. Ульяновск, ул. Л. Толстого, 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., ORCID: http://orcid.org/0000-0002-9006-2023

Шарафутдинов Марат Гакифович – кандидат медицинских наук, заведующий кафедрой онкологии и лучевой диагностики медицинского факультета им. Т.З. Биктимирова, ФГБОУ ВО «Ульяновский государственный университет». 432017, Россия, г. Ульяновск, ул. Л. Толстого, 42; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.; ORCID: http://orcid.org/0000-0002-8782-4111

 

Образец цитирования

Панченко И.С., Родионов В.В., Панченко С.В., Шарафутдинов М.Г. Особенности клиники, прогноза и лечения андроген-рецептор-позитивного трижды негативного рака молочной железы. Ульяновский медико-биологический журнал. 2021; 2: 83–96. DOI: 10.34014/2227-1848-2021-2-83-96.