Ulyanovsk Medico-biological Journal

NORMAL AND PATHOLOGICAL PHYSIOLOGY

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THE EVALUATION OF INSPIRATORY MUSCLE FUNCTION BY MEASURING OF «TENSION – TIME» INDEX

M.O. Segizbaeva, N.P. Aleksandrova

I.P. Pavlov Institute of Physiology RAS, St. Petersburg

 

Review examines the possibility of using different versions of the «tension – time» index in order to assess the inspiratory muscles function and to determine the reserve capacity of the respiratory muscles in health and diseases of the broncho-pulmonary, cardiovascular, neuro-muscular system, under which the load on the respiratory muscles increases, that can lead to respiratory failure. The absolute values of the index are present in normal and in various diseases, based on the literature and our own data. Possible reasons for changing the values of the index, causing the growth rate in excess of the respiratory muscles, as well as methodological approaches to the correction in the identification of early signs of inspiratory muscle fatigue development are discussed.

Keywords: index of «tension – time», inspiratory muscle fatigue, obstructive lung diseases.

 

References

  1. Сегизбаева М. О. Оценка устойчивости разных групп инспираторных мышц к утомлению при физической нагрузке на фоне моделируемой обструкции дыхательных путей / М. О. Сегизбаева, Н. П. Александрова // Физиология человека. – 2014. – Т. 40, № 5.

  2. A simple noninvasive pressure-time index at the mouth to measure respiratory load during acute exacerbation of COPD. A comparison with normal volunteers / C. Gonzalez [et al.] // Respir. Med. – 2003. – Vol. 97, № 4. – P. 415–420.

  3. Inspiratory muscle activity during incremental exercise in obese men / M. Chlif [et al.] // Int. J. Obes (Lond.). – 2007. – Vol. 31, № 9. – P. 1456–1463.

  4. Noninvasive measurement of the maximum relaxation rate of inspiratory muscles in patients with neuromuscular disorders / F. Garcia-Rio [et al.] // Respiration. – 2006. – Vol. 73, № 4. – P. 474–480.

  5. Bellemare F. Effect of pressure and timing of contraction on human diaphragm fatigue / F. Bellemare, A. Grassino // J. Appl. Physiol. – 1982. – Vol. 53, № 5. – P. 1190–1195.

  6. Bellemare F. Evaluation of human diaphragm fatigue / F. Bellemare, A. Grassino // J. Appl. Physiol. – 1982. – Vol. 53, № 5. – P. 1196–1206.

  7. Determinants of the tension-time index of inspiratory muscles in children with cystic fibrosis / M. Hayot [et al.] // Pediatr. Pulmonol. – 1997. – Vol. 23, № 5. – P. 336–343.

  8. Electromyographic validation of the mouth pressure-time index: a noninvasive assessment of inspiratory muscle load / J. P. deTorres [et al.] // Respir. Med. – 2003. – Vol. 97, № 9. – P. 1006–1013.

  9. Gaultier C. Inspiratory force reserve of the respiratory muscles in children with chronic obstruc-tive pulmonary diseases / C. Gaultier, M. Boule, F. Girard // Am. Rev. Respir. Dis. – 1985. – Vol. 131. – P. 811–815.

  10. Milic-Emili J. Relationship between neuromuscular respiratory drive and ventilatory output / J. Milic-Emili, W. A. Zin // Handbook of Physiology. The Respiratory System. Mechanics of Breathing. – Bethesda, MD : Am. Physiol. Soc., 1986. – Sect 3. – Vol. III, pt 2. – P. 635–646.

  11. Noninvasive assessment of inspiratory muscle function during exercise / M. Hayot [et al.] // Am. J. Respir. Crit. Care Med. – 2000. – Vol. 162, № 6. – P. 2201–2207.

  12. Non-invasive assessment of inspiratory muscle performance during exercise in patients with chronic heart failure / N. Vibarel [et al.] // Eur. Heart J. – 1998. – Vol. 19, № 5. – P. 766–773.

  13. Noninvasive assessment of the tension-time index of the inspiratory muscles at rest in obese male subjects / M. Chlif [et al.] // Int. J. Obes (Lond.). – 2005. – Vol. 29, № 12. – P. 1478–1483.

  14. Noninvasive determination of the tension-time index in Duchenne muscular dystrophy / A. Hahn [et al.] // Am. J. Phys. Med. Rehabil. – 2009. – Vol. 88, № 4. – P. 322–327.

  15. Noninvasive measurement of the tension-time index in children with neuromuscular disease / L. T. Mulreany [et al.] // J. Appl. Physiol. – 2003. – Vol. 95. – P. 931–937.

  16. Non-invasive tension-time index in relation to severity of disease / A. Hahn [et al.] // Pediatr Pulmonol. – 2008. – Vol. 43, № 10. – P. 973–981.

  17. Prediction of exturbation outcome in infants using the tension-time index / A. Currie [et al.] // Archю Disю Fetal Neonatal Ed. – 2011. – Vol. 96, № 4. – P. 265–269.

  18. Ramonatxo M. Validation of non-invasive tension-time index of respiratory muscles / M. Ramonatxo, P. Boulard, Ch. Prefaut // J. Appl. Physiol. – 1995. – Vol. 78. – P. 646–653.

  19. Respiratory muscle deoxygenation during exercise in patients with heart failure demonstrated with near-infrared spectroscopy / D. Mancini [et al.] // J. Am. Coll Cardiol. – 1991. – Vol. 18. – P. 492–498.

  20. Respiratory muscle function and dyspnea in patients with chronic heart failure / D. Mancini [et al.] // Circulation. – 1992. – Vol. 86. – P. 909–918.

  21. Tension-time index of inspiratory muscles in COPD patients: role of airway obstruction / M. Hayot [et al.] // Respir. Med. – 1998. – Vol. 92, № 6. – P. 828–835.

  22. The sensation of dyspnea during exercise is not determined by the work of breathing in patients with heart failure / D. M. Mancini [et al.] // J. Am. Coll Cardiol. – 1996. – Vol. 28, № 2. – P. 391–395.

  23. Timing and driving components of the breathing strategy in children with cystic fibrosis during exercise / D. Keochkerian [et al.] // Pediatr. Pulmonol. – 2005. – Vol. 40, № 5. – P. 449–456.

  24. Ventilatory muscles during exercise in air and oxygen in normal men / P. T. Bye [et al.] // J. Appl. Physiol. – 1984. – Vol. 56, № 2. – P. 464–471.

  25. Whitelaw W. A. Airway occlusion pressure / W. A. Whitelaw, J. P. Derenne // J. Appl. Physiol. – 1993. – Vol. 74. – P. 1475–483.

 

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УДК 612.217

ПРИМЕНЕНИЕ ИНДЕКСА «НАПРЯЖЕНИЕ – ВРЕМЯ» ДЛЯ ОЦЕНКИ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ИНСПИРАТОРНЫХ МЫШЦ

М.О. Сегизбаева, Н.П. Александрова

ФГБУН «Институт физиологии им. И.П. Павлова РАН», г. Санкт-Петербург

 

В обзоре рассматривается возможность применения разных модификаций расчетного индекса «напряжение – время» для оценки функционального состояния и определения резервных возможностей инспираторных мышц в норме и при заболеваниях бронхолегочной, сердечно-сосудистой, нейромышечной систем, при которых возрастает нагрузка на дыхательную мускулатуру, что может приводить к развитию вентиляторной недостаточности. На основании литературных и собственных данных приводятся абсолютные значения показателя индекса в норме, при выполнении мышечной нагрузки и при различных заболеваниях. Обсуждаются возможные причины повышения значений индекса при избыточной работе дыхательных мышц, а также методические подходы к коррекции при идентификации начальных признаков развития утомления инспираторной мускулатуры.

Ключевые слова: индекс «напряжение – время», утомление инспираторных мышц, обструктивные заболевания легких

 

Литература

  1. Сегизбаева М. О. Оценка устойчивости разных групп инспираторных мышц к утомлению при физической нагрузке на фоне моделируемой обструкции дыхательных путей / М. О. Сегизбаева, Н. П. Александрова // Физиология человека. – 2014. – Т. 40, № 5.

  2. A simple noninvasive pressure-time index at the mouth to measure respiratory load during acute exacerbation of COPD. A comparison with normal volunteers / C. Gonzalez [et al.] // Respir. Med. – 2003. – Vol. 97, № 4. – P. 415–420.

  3. Inspiratory muscle activity during incremental exercise in obese men / M. Chlif [et al.] // Int. J. Obes (Lond.). – 2007. – Vol. 31, № 9. – P. 1456–1463.

  4. Noninvasive measurement of the maximum relaxation rate of inspiratory muscles in patients with neuromuscular disorders / F. Garcia-Rio [et al.] // Respiration. – 2006. – Vol. 73, № 4. – P. 474–480.

  5. Bellemare F. Effect of pressure and timing of contraction on human diaphragm fatigue / F. Bellemare, A. Grassino // J. Appl. Physiol. – 1982. – Vol. 53, № 5. – P. 1190–1195.

  6. Bellemare F. Evaluation of human diaphragm fatigue / F. Bellemare, A. Grassino // J. Appl. Physiol. – 1982. – Vol. 53, № 5. – P. 1196–1206.

  7. Determinants of the tension-time index of inspiratory muscles in children with cystic fibrosis / M. Hayot [et al.] // Pediatr. Pulmonol. – 1997. – Vol. 23, № 5. – P. 336–343.

  8. Electromyographic validation of the mouth pressure-time index: a noninvasive assessment of inspiratory muscle load / J. P. deTorres [et al.] // Respir. Med. – 2003. – Vol. 97, № 9. – P. 1006–1013.

  9. Gaultier C. Inspiratory force reserve of the respiratory muscles in children with chronic obstruc-tive pulmonary diseases / C. Gaultier, M. Boule, F. Girard // Am. Rev. Respir. Dis. – 1985. – Vol. 131. – P. 811–815.

  10. Milic-Emili J. Relationship between neuromuscular respiratory drive and ventilatory output / J. Milic-Emili, W. A. Zin // Handbook of Physiology. The Respiratory System. Mechanics of Breathing. – Bethesda, MD : Am. Physiol. Soc., 1986. – Sect 3. – Vol. III, pt 2. – P. 635–646.

  11. Noninvasive assessment of inspiratory muscle function during exercise / M. Hayot [et al.] // Am. J. Respir. Crit. Care Med. – 2000. – Vol. 162, № 6. – P. 2201–2207.

  12. Non-invasive assessment of inspiratory muscle performance during exercise in patients with chronic heart failure / N. Vibarel [et al.] // Eur. Heart J. – 1998. – Vol. 19, № 5. – P. 766–773.

  13. Noninvasive assessment of the tension-time index of the inspiratory muscles at rest in obese male subjects / M. Chlif [et al.] // Int. J. Obes (Lond.). – 2005. – Vol. 29, № 12. – P. 1478–1483.

  14. Noninvasive determination of the tension-time index in Duchenne muscular dystrophy / A. Hahn [et al.] // Am. J. Phys. Med. Rehabil. – 2009. – Vol. 88, № 4. – P. 322–327.

  15. Noninvasive measurement of the tension-time index in children with neuromuscular disease / L. T. Mulreany [et al.] // J. Appl. Physiol. – 2003. – Vol. 95. – P. 931–937.

  16. Non-invasive tension-time index in relation to severity of disease / A. Hahn [et al.] // Pediatr Pulmonol. – 2008. – Vol. 43, № 10. – P. 973–981.

  17. Prediction of exturbation outcome in infants using the tension-time index / A. Currie [et al.] // Archю Disю Fetal Neonatal Ed. – 2011. – Vol. 96, № 4. – P. 265–269.

  18. Ramonatxo M. Validation of non-invasive tension-time index of respiratory muscles / M. Ramonatxo, P. Boulard, Ch. Prefaut // J. Appl. Physiol. – 1995. – Vol. 78. – P. 646–653.

  19. Respiratory muscle deoxygenation during exercise in patients with heart failure demonstrated with near-infrared spectroscopy / D. Mancini [et al.] // J. Am. Coll Cardiol. – 1991. – Vol. 18. – P. 492–498.

  20. Respiratory muscle function and dyspnea in patients with chronic heart failure / D. Mancini [et al.] // Circulation. – 1992. – Vol. 86. – P. 909–918.

  21. Tension-time index of inspiratory muscles in COPD patients: role of airway obstruction / M. Hayot [et al.] // Respir. Med. – 1998. – Vol. 92, № 6. – P. 828–835.

  22. The sensation of dyspnea during exercise is not determined by the work of breathing in patients with heart failure / D. M. Mancini [et al.] // J. Am. Coll Cardiol. – 1996. – Vol. 28, № 2. – P. 391–395.

  23. Timing and driving components of the breathing strategy in children with cystic fibrosis during exercise / D. Keochkerian [et al.] // Pediatr. Pulmonol. – 2005. – Vol. 40, № 5. – P. 449–456.

  24. Ventilatory muscles during exercise in air and oxygen in normal men / P. T. Bye [et al.] // J. Appl. Physiol. – 1984. – Vol. 56, № 2. – P. 464–471.

  25. Whitelaw W. A. Airway occlusion pressure / W. A. Whitelaw, J. P. Derenne // J. Appl. Physiol. – 1993. – Vol. 74. – P. 1475–483.