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INTERSYSTEM CORRELATION OF RESPIRATION AND HEMODYNAMICS DURING POSTURAL CHANGES

Zh.A. Donina, N.P. Aleksandrova

Pavlov Institute of Physiology Russian Academy of Sciences

The effects of passive head-up and head-down tilting on intersystem correlation respiration and hemodynamics were investigated in anesthetized spontaneously breathing cats. Studies have shown that marked changes in circulation, functional residual capacity and compliance occur within the fist minutes of postural change. Changes in circulatory and respiratory modulation throughout postural test were opposite and linearly related to the sine of the tilt angle. This data indicate that the primarily changes in cardiorespiratory system were influenced by the blood distribution dependent from hydrostatic effect of gravity.

Keywords: postural changes, circulatory and respiratory modulation, hydrostatic effect of gravity.

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2. Butler G. C. Cardiovascular response to 4 hours of 6 degrees head-down tilt or of 30 degrees head-up tilt bed rest / G. C. Butler, H. C. Xing, R. L. Hughson // Aviat., Space and Environ Med. – 1990. – Vol. 61, № 3. – P. 240–246.

3. Cardio-respiratory changes during the onset of head-down tilt / C. Soubiran [et al.] // Aviat. Space Environ. Med. – 1996. – Vol. 67, № 7. – P. 648–653.

4. Effect of gravity and posture on lung mechanics / D. Bettinelli [et al.] // J. Appl. Physiol. – 2002. – Vol. 93, № 6. – P. 2044–2052.

5. Effect of gravity on chest wall mechanics / D. Bettinelli [et al.] // J. Appl. Physiol. – 2002. – Vol. 92. – P. 709–716.

6. Effects of 12 days exposure to simulated microgravity on central circulatory hemodynamics in the rhesus monkey / V. Convertino [et al.] // Acta Astronautica. – 1998. – Vol. 42. – P. 255–263.

7. Haouzi P. Respiratory effects of changing the volume load imposed on the peripheral venous system / P. Haouzi, H. Bell // Respir. Physiol. Neurobiol. – 2010. – Vol. 171, № 3. – P. 175–180.

8. Regulation of body fluid compartments during short-term spaceflight / C. Leach [et al.] // J. Appl. Physiol. – 1996. – Vol. 81. – P. 105–116.

9. Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow / A. Henderson [et al.] // J. Appl. Physiol. – 2006. – Vol. 101, № 2. – P. 583–589.

10. Toska K. Dynamic time course of hemodynamic responses after passive head-up tilt and tilt back to supine position / K. Toska, L. Walloe // J. Appl. Physiol. – 2002. – Vol. 92. – P. 1671–1676.

11. West J. B. Chest volume and shape and intrapleural pressure in microgravity / J. B. West, G. K. Prisk // J. Appl. Physiol. – 1999. – Vol. 87. – P. 1240–1241.

12. Wieling W. Extracellular fluid volume expansion in patients with posturally related syncope / W. Wieling, J. J. van Liehout, H. Ten // Clin. Sci. (Colch.). – 1998. – Vol. 94. – P. 347–352

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УДК 612.217

ВЗАИМОЗАВИСИМЫЕ РЕАКЦИИ ДЫХАНИЯ И ЦЕНТРАЛЬНОЙ ГЕМОДИНАМИКИ ПРИ ПОСТУРАЛЬНЫХ ВОЗДЕЙСТВИЯХ

Ж.А. Донина, Н.П. Александрова

ФГБУ «Институт физиологии им. И.П. Павлова РАН», г. Санкт-Петербург

Установлено, что пассивное орто- и антиортостатическое воздействие сопровождается разнонаправленными гемодинамическими сдвигами в краниальной и каудальной частях туловища. Изменение основных показателей структуры легких и биомеханических характеристик дыхательного аппарата находится в линейной зависимости от интенсивности сдвигов гемодинамики и имеет противоположную модальность, что свидетельствует о пассивной природе нарушений переходного периода постуральных воздействий, обусловленных преимущественно физическим фактором – гравитационно-зависимым перераспределением жидкостных сред организма.

Ключевые слова: постуральные воздействия, гемодинамика, структура легких, биомеханические характеристики дыхательного аппарата.

Литература

1. Baranov V. M. The external respiration and gas exchanges in space missions / V. M. Baranov, M. A. Tihonov, A. N. Kotov // Acta astronaut. – 1992. – Vol. 27. – P. 45–50.

2. Butler G. C. Cardiovascular response to 4 hours of 6 degrees head-down tilt or of 30 degrees head-up tilt bed rest / G. C. Butler, H. C. Xing, R. L. Hughson // Aviat., Space and Environ Med. – 1990. – Vol. 61, № 3. – P. 240–246.

3. Cardio-respiratory changes during the onset of head-down tilt / C. Soubiran [et al.] // Aviat. Space Environ. Med. – 1996. – Vol. 67, № 7. – P. 648–653.

4. Effect of gravity and posture on lung mechanics / D. Bettinelli [et al.] // J. Appl. Physiol. – 2002. – Vol. 93, № 6. – P. 2044–2052.

5. Effect of gravity on chest wall mechanics / D. Bettinelli [et al.] // J. Appl. Physiol. – 2002. – Vol. 92. – P. 709–716.

6. Effects of 12 days exposure to simulated microgravity on central circulatory hemodynamics in the rhesus monkey / V. Convertino [et al.] // Acta Astronautica. – 1998. – Vol. 42. – P. 255–263.

7. Haouzi P. Respiratory effects of changing the volume load imposed on the peripheral venous system / P. Haouzi, H. Bell // Respir. Physiol. Neurobiol. – 2010. – Vol. 171, № 3. – P. 175–180.

8. Regulation of body fluid compartments during short-term spaceflight / C. Leach [et al.] // J. Appl. Physiol. – 1996. – Vol. 81. – P. 105–116.

9. Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow / A. Henderson [et al.] // J. Appl. Physiol. – 2006. – Vol. 101, № 2. – P. 583–589.

10. Toska K. Dynamic time course of hemodynamic responses after passive head-up tilt and tilt back to supine position / K. Toska, L. Walloe // J. Appl. Physiol. – 2002. – Vol. 92. – P. 1671–1676.

11. West J. B. Chest volume and shape and intrapleural pressure in microgravity / J. B. West, G. K. Prisk // J. Appl. Physiol. – 1999. – Vol. 87. – P. 1240–1241.

12. Wieling W. Extracellular fluid volume expansion in patients with posturally related syncope / W. Wieling, J. J. van Liehout, H. Ten // Clin. Sci. (Colch.). – 1998. – Vol. 94. – P. 347–352