Ulyanovsk Medico-biological Journal

ONCOLOGY

Download article

REPRODUCTIVE TECHNOLOGIES AND BREAST CANCER

R.M. Khayrullin1, R.T. Sulaimanova2, V.V. Kometova3, L.R. Usupova2

1Ulyanovsk State University,

2Bashkirsky State Medical University, Ufa,

3Ulyanovsk Regional Clinical Oncological Hospital

 

In this paper we consider the probability of influence hyperestrogenia during fetal development of female on the risk of breast cancer. It is shown that the use of reproductive technologies using synthetic hormones and xenobiotics with estrogenic action of mutagenic effects at high risk of neoplastic processes in the breast tissue in adulthood among children born female. The substantiation of the need to control doses and concentrations estrogen drugs during conception and gestation. It is necessary to study the use of hormones and their analogs in reproductive technologies as predictors of breast cancer.

Keywords: breast cancer, reproductive technologies, steroid hormones, estrogen receptors, carcinogenesis.

 

References

  1. Charlier C. Environmental dichlor-o-diphe-nyl-trichlorethane or hexachlorobenzene exposure and breast cancer: is there a risk? / C. Charlier, F. M. Foidart, F. Pitance // Clin. Chem. Lab. Med. – 2004. – Vol. 42 (2). – P. 222–227.

  2. Choi J. p53 in embryonic development: maintaining a fine balance / J. Choi, L. A. Donehower // Cell Mol. Life Sci. – 1999. – Vol. 55 (1). – P. 38–47.

  3. Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis / T. M. Savarese [et al.] // Breast Cancer Res. – 2007. – Vol. 9 (3). – P. R29. – URL: http://doi:10.1186/bcr1674.

  4. Den Hond E. Endocrine disrupters and human puberty / E. Den Hond, G. Schoeters // Int. J. Androl. – 2006. – Vol. 29 (1). – P. 264–271.

  5. EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice / A. P. Morel [et al.] // PLoS Genet. – 2012. – Vol. 8 (5). – P. e1002723. – URL: http://doi: 10.1371/journal.pgen.1002723.

  6. Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression / O. Kovalchuk [et al.] // Cell Cycle. – 2007. – Vol. 15, № 6 (16). – Р. 2010–2018.

  7. Gene expression profile of terminal end buds in rat mammary glands exposed to diethylstilbestrol in neonatal period / Y. Umekita [et al.] // Toxicol Lett. – 2011. – Vol. 10, № 205 (1). – P. 15–25.

  8. Godfrey K. M. Fetal programming and adult health / K. M. Godfrey, D. J. Barker // Public Health Nutr. – 2001. – Vol. 4(2B). – P. 611–624.

  9. Hatsumi T. Downregulation of estrogen receptor gene expression by exogenous 17beta-estradiol in the mammary glands of lactating mice / T. Hatsumi, Y. Yamamuro // Exp. Biol. Med. (Maywood). – 2006. – Vol. 231 (3). – P. 311–316.

  10. Increased breast cancer risk after multiple implantation in IVF: a cohort study / E. Groeneveld [et al.] // ESHRE. – 2013. – Abstract L13. – P. 1178.

  11. Lau C. Embryonic and fetal programming of physiological disorders in adulthood / C. Lau, J. M. Rogers // Birth Defects Res. C. Embryo Today. – 2004. – Vol. 72 (4). – P. 300–312.

  12. Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer / S. Davidovich [et al.] // Breast Cancer Res. – 2008. – Vol. 10 (4). – P. R63.

  13. Pesticide Monitoring Program – 2009. Pesticide Report. U.S. Food and Drug Administration. – 2009. – 39 p.

  14. Promotion of estrogen-induced mammary gland carcinogenesis by androgen in the male Noble rat: Probable mediation by steroid receptors / D. Z. J. Liao [et al.] // Carcinogenesis. – 1998. – Vol. 19 (12). – P. 2173–2180.

  15. Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4 / H. Chander [et al.] // PLoS One. – 2011. – Vol. 6 (8). – P. e22456. – URL: http://doi: 10.1371/journal. pone. 0022456.

  16. Snedeker S. M. Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin / S. M. Snedeker // Environ Health Perspect. – 2001. – Vol. 109 (suppl. 1). – P. 35–47.

  17. Toxicological profile for DDT, DDE, and DDD. Agency for Toxic Substances and Disease Registry. – 2002. – 477 p.

 

Скачать статью

УДК 616-006.66

РЕПРОДУКТИВНЫЕ ТЕХНОЛОГИИ И РАК МОЛОЧНОЙ ЖЕЛЕЗЫ

Р.М. Хайруллин1, Р.Т. Сулайманова2, В.В. Кометова3, Л.Р. Юсупова1

1ФГБОУ ВПО «Ульяновский государственный университет»,

2ГБОУ ВПО «Башкирский государственный медицинский университет», г. Уфа,

3ГУЗ «Областной клинический онкологический диспансер», г. Ульяновск

 

В работе рассмотрена вероятность влияния гиперэстрогении во время внутриутробного развития плода женского пола на риск возникновения рака молочной железы. Показано, что применение репродуктивных технологий с использованием синтетических гормонов и ксенобиотиков с эстрогеноподобным действием обладает мутагенным эффектом с высоким риском развития неопластических процессов в тканях молочной железы во взрослом состоянии у рожденных детей женского пола. Дано обоснование необходимости контроля доз и концентраций эстрогенсодержащих препаратов во время зачатия и вынашивания плодов. Доказана необходимость изучения использования гормональных препаратов и их аналогов в репродуктивных технологиях как предикторов развития рака молочной железы.

Ключевые слова: рак молочной железы, репродуктивные технологии, стероидные гормоны, эстрогеновые рецепторы, канцерогенез.

 

Литература

  1. Charlier C. Environmental dichlor-o-diphe-nyl-trichlorethane or hexachlorobenzene exposure and breast cancer: is there a risk? / C. Charlier, F. M. Foidart, F. Pitance // Clin. Chem. Lab. Med. – 2004. – Vol. 42 (2). – P. 222–227.

  2. Choi J. p53 in embryonic development: maintaining a fine balance / J. Choi, L. A. Donehower // Cell Mol. Life Sci. – 1999. – Vol. 55 (1). – P. 38–47.

  3. Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis / T. M. Savarese [et al.] // Breast Cancer Res. – 2007. – Vol. 9 (3). – P. R29. – URL: http://doi:10.1186/bcr1674.

  4. Den Hond E. Endocrine disrupters and human puberty / E. Den Hond, G. Schoeters // Int. J. Androl. – 2006. – Vol. 29 (1). – P. 264–271.

  5. EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice / A. P. Morel [et al.] // PLoS Genet. – 2012. – Vol. 8 (5). – P. e1002723. – URL: http://doi: 10.1371/journal.pgen.1002723.

  6. Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression / O. Kovalchuk [et al.] // Cell Cycle. – 2007. – Vol. 15, № 6 (16). – Р. 2010–2018.

  7. Gene expression profile of terminal end buds in rat mammary glands exposed to diethylstilbestrol in neonatal period / Y. Umekita [et al.] // Toxicol Lett. – 2011. – Vol. 10, № 205 (1). – P. 15–25.

  8. Godfrey K. M. Fetal programming and adult health / K. M. Godfrey, D. J. Barker // Public Health Nutr. – 2001. – Vol. 4(2B). – P. 611–624.

  9. Hatsumi T. Downregulation of estrogen receptor gene expression by exogenous 17beta-estradiol in the mammary glands of lactating mice / T. Hatsumi, Y. Yamamuro // Exp. Biol. Med. (Maywood). – 2006. – Vol. 231 (3). – P. 311–316.

  10. Increased breast cancer risk after multiple implantation in IVF: a cohort study / E. Groeneveld [et al.] // ESHRE. – 2013. – Abstract L13. – P. 1178.

  11. Lau C. Embryonic and fetal programming of physiological disorders in adulthood / C. Lau, J. M. Rogers // Birth Defects Res. C. Embryo Today. – 2004. – Vol. 72 (4). – P. 300–312.

  12. Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer / S. Davidovich [et al.] // Breast Cancer Res. – 2008. – Vol. 10 (4). – P. R63.

  13. Pesticide Monitoring Program – 2009. Pesticide Report. U.S. Food and Drug Administration. – 2009. – 39 p.

  14. Promotion of estrogen-induced mammary gland carcinogenesis by androgen in the male Noble rat: Probable mediation by steroid receptors / D. Z. J. Liao [et al.] // Carcinogenesis. – 1998. – Vol. 19 (12). – P. 2173–2180.

  15. Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4 / H. Chander [et al.] // PLoS One. – 2011. – Vol. 6 (8). – P. e22456. – URL: http://doi: 10.1371/journal. pone. 0022456.

  16. Snedeker S. M. Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin / S. M. Snedeker // Environ Health Perspect. – 2001. – Vol. 109 (suppl. 1). – P. 35–47.

  17. Toxicological profile for DDT, DDE, and DDD. Agency for Toxic Substances and Disease Registry. – 2002. – 477 p.