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THE HISTORY OF JUXTAGLOMERULAR APPARATUS OF THE KIDNEY RESEARCH

V.I. Arav1, E.V. Slesareva1, V.V. Popov2, K.A. Kuchina1, R.V. Ureneva1

1Ulyanovsk State University,

2Ulyanovsk Region Children’s Hospital

 

The history of juxtaglomerular apparatus of the kidney researching began in the end of 19th century from the renin discovery. This fact stimulated the opening of structures engaged synthesis of renin and study of the regulation and functional significance of renin and juxtaglomerular apparatus. These issues have been in the main resolved in the mid-20th century, which led to an understanding of the crucial role of the juxtaglomerular apparatus in the water and salt homeostasis preservation. In the early 80-ies of the 20th century the elucidation of the renin role in the pathogenesis of hypertension stimulated the study of its production mechanisms and intracellular mechanisms of its isolation. The examining of these issues continues now, and it is still far from the final solution .

Keywords: juxtaglomerular apparatus, dense spot, renin.

 

References

  1. A protease processing site is essential for prorenin sorting to the regulated secretary pathway / V. Brechle [et al.] // J. Biol. Chem. – 1996. – Vol. 271. – P. 636–640.

  2. Beierwaltes W. H. The role of calcium in the regulation of rennin secretion / W. H. Beierwaltes // Am. J. Physiol. Renal Physiol. – 2009. – Vol. 29.

  3. Celoria G. C. Role of the macula densa in relation to the granulation ot the renal juxtaglomerular cells / G. C. Сeloria, R. Puche // Acta Physiol lat Am. – 1967. – Vol. 17 (1). – P. 6–14.

  4. Connekcin 40 regulates renin production and blood pressure / N. Krattinger [et al.] // Kidney Int. – 2007. – Vol. 72. – P. 814–822.

  5. Connexin 40 is essential for the pressure control of renin synthesis and secretion / C. Wagner [et al.] // Circ. Res. – 2007. – Vol. 100. – P. 556–563.

  6. Eknoyan G. On the central role of the kidney in the recognition, conceptual evolution, and understanding of hypertention / G. Eknoyan // Adv. Chronic Kidney Dis. – 2004. – Vol. 11. – P. 192–196.

  7. Eknoyan G. The Juxtaglomerular apparatus of Norbert Goormaghtigh – a critical appraisal / G. Eknoyan, R. Ruben, N. Lameire // Nephrol. Dial Transplant. – 2009. – Vol. 24. – P. 3876–3881.

  8. Goormaghtigh N. Existance of an endocrine gland in the media of renal arterioles / N. Goormaghtigh // Proc. Soc. Exp. Biol. Med. – 1939. – Vol. 42. – P. 688–689.

  9. Goormaghtigh N. La scrlerose vasculaire renale experimentale du apin / N. Goormaghtigh // Ann. Anat Pathol. – 1931. – Vol. 8. – P. 587–604.

  10. Goormaghtigh N. L'appareil neuro-myo-arterial juxtaglomerulaire du rein: ses reactions en pathologic et ses rapports avec le tube urinifere / N. Goormaghtigh // Compt. Rend. Soc. Biol. – 1937. – Vol. 129. – P. 293–296.

  11. Goormaghtigh N. Les segments neuro-myo-arteriels juxtaglomerulaires du renin / N. Goormagh-tigh // Arch. Biol. – 1932. – Vol. 43. – P. 575–591.

  12. Goormaghtigh N. Sclerose vasculaire du rein apres denervation des sinus carotidience et section des nerfs depresseurs / N. Goormaghtigh // Compt. Rend. Soc. Biol. – 1931. – Vol. 106. – P. 1254–1257.

  13. Guilan R. A. The juxtaglomerular complex / R. A. Guilan, S. Zelman, F. J. Murphy // Arch. Pathol. – 1967. – Vol. 84 (6). – P. 598–600.

  14. Kurtz A. Renin release: sites, mechanisms and control / A. Kurtz // Ann. Rew. Physiol. – 2011. – Vol. 73. – P. 377–390.

  15. Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the exxraglomerular mesangium / L. Kurtz [et al.] // J. Am. Soc. Nephrol. – 2007. – Vol. 18. – P. 1103–1111.

  16. Marks L. S. Tigerstedt and the discowery of renin. A historical note / L. S. Marks, M. H. Maxwell // Hypertension. – 1979. – Vol. 1. – P. 384–388.

  17. Metaplasia of smoth muscle cells into juxtaglomerular cells in the juxtaglomerular apparatus, arteries and arterioles of the ischemic kidney / M. Cantin [et al.] // Am. J. Pathol. – 1977. – Vol. 87, № 3. – P. 581–592.

  18. Oberling C. R. L'existense d'une housse neuromusculaire au niveau des arteres glomerulaires de s'Homme / C. R. Oberling // Compt. Rend. Acad. Sci. – 1927. – Vol. 184. – P. 1200–1202.

  19. Peti-Peterdi J. Macula densa sensing and signaling mechanisms of rennin release / I. Peti-Peterdi, R. C. Harris // J. Am. Soc. Nephrol. – 2010. – Vol. 21 (7). – P. 1093–1096.

  20. Reeves G. Sensitivity of the renal macula densa to urinary sodium proc. / G. Reeves, S. C. Som-mers // Soc. Exp. Biol. Med. – 1965. – Vol. 120 (2). – P. 324–326.

  21. Renin cells are precursors, for multiple cell types that switch to the renin phenotype when homestasis is threatened / Sequeira Lopez M. L. [et al.] // Dev. cell. – 2004. – Vol. 6. – P. 719–728.

  22. Renin release / F. Schweda [et al.] // Physiology. – 2007. – Vol. 22. – P. 310–319.

  23. Ruyter J. H. C. Uber einen Merkwurdigen abscnitt der Vas Afferentiv in der Mauseniere / J. H. C. Ruyter // Ztschr Mikrosk Anal Forsch. – 1925. – Vol. 2. – P. 242–248.

  24. Sequeira Lopez M. L. Novel mechanisms for the control of renin synthesis and release / Sequeira Lopez M. L., R. A. Gomez // Curr. Hypertens Rep. – 2010. – Vol. 12 (1). – P. 26–32.

  25. Succinate receptor (GPR 91) activation in macula densa cells causes renin release / S. L. Vargas [et al.] // J. Am. Soc. Nephrol. – 2009. – Vol. 20. –P. 1002–1011.

  26. Turau K. Renal blood fiow and dynamics of glomerular filtration: Evolution of a concept from Carl Ludwig to the present day / K. Turau, J. M. Davis, D. A. Häberle // Renal Physiology. People and Jdeas / Carl W. Gottschalk, Robert W. Berliner, Gerhard H. Giebish (eds.). – Bethesda, MD : American Physiological Society, 1987. – P. 31–61.

  27. Zimermann K. W. Uber den Bau des Glomerulus der menschlichen / K. W. Zimermann // Niere Z. Mikr. Anat. Forsch. – 1929. – Vol. 19. – P. 520–552.

  28. Zimermann K. W. Uber der Bau des Glomerulus der Saugerniere: Weittere Mitteilunger / K. W. Zimermann // Niere Z. Mikr. Anat. Forsch. – 1933. – Vol. 32. – P. 176–278.

 

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УДК 611-018:616.61:616.12–008.331.1

ИСТОРИЯ ИССЛЕДОВАНИЯ ЮКСТАГЛОМЕРУЛЯРНОГО АППАРАТА

В.И. Арав1, Е.В. Слесарева1, В.В. Попов2, К.А. Кучина1, Р.В. Уренева1

1Ульяновский государственный университет,

2Ульяновская областная детская больница

 

История исследования юкстагломерулярного аппарата почки началась в конце XIX в. с открытия ренина. Это стимулировало открытие структур, осуществляющих синтез ренина, изучение регуляции его выделения и функционального значения ренина и юкстагломерулярного аппарата. Эти вопросы были в основном изучены в середине XX столетия, что привело к пониманию решающей роли юкстагломерулярного аппарата в сохранении водно-солевого гомеостаза. Выяснение роли ренина в патогенезе гипертонической болезни стимулировало в начале 80-х гг. XX столетия изучение механизмов его продукции и внутриклеточных механизмов его выделения. Исследование этих вопросов продолжается и в настоящее время, и они все еще далеки от окончательного разрешения.

Ключевые слова: юкстагломерулярный аппарат, плотное пятно, ренин.

 

Литература

  1. A protease processing site is essential for prorenin sorting to the regulated secretary pathway / V. Brechle [et al.] // J. Biol. Chem. – 1996. – Vol. 271. – P. 636–640.

  2. Beierwaltes W. H. The role of calcium in the regulation of rennin secretion / W. H. Beierwaltes // Am. J. Physiol. Renal Physiol. – 2009. – Vol. 29.

  3. Celoria G. C. Role of the macula densa in relation to the granulation ot the renal juxtaglomerular cells / G. C. Сeloria, R. Puche // Acta Physiol lat Am. – 1967. – Vol. 17 (1). – P. 6–14.

  4. Connekcin 40 regulates renin production and blood pressure / N. Krattinger [et al.] // Kidney Int. – 2007. – Vol. 72. – P. 814–822.

  5. Connexin 40 is essential for the pressure control of renin synthesis and secretion / C. Wagner [et al.] // Circ. Res. – 2007. – Vol. 100. – P. 556–563.

  6. Eknoyan G. On the central role of the kidney in the recognition, conceptual evolution, and understanding of hypertention / G. Eknoyan // Adv. Chronic Kidney Dis. – 2004. – Vol. 11. – P. 192–196.

  7. Eknoyan G. The Juxtaglomerular apparatus of Norbert Goormaghtigh – a critical appraisal / G. Eknoyan, R. Ruben, N. Lameire // Nephrol. Dial Transplant. – 2009. – Vol. 24. – P. 3876–3881.

  8. Goormaghtigh N. Existance of an endocrine gland in the media of renal arterioles / N. Goormaghtigh // Proc. Soc. Exp. Biol. Med. – 1939. – Vol. 42. – P. 688–689.

  9. Goormaghtigh N. La scrlerose vasculaire renale experimentale du apin / N. Goormaghtigh // Ann. Anat Pathol. – 1931. – Vol. 8. – P. 587–604.

  10. Goormaghtigh N. L'appareil neuro-myo-arterial juxtaglomerulaire du rein: ses reactions en pathologic et ses rapports avec le tube urinifere / N. Goormaghtigh // Compt. Rend. Soc. Biol. – 1937. – Vol. 129. – P. 293–296.

  11. Goormaghtigh N. Les segments neuro-myo-arteriels juxtaglomerulaires du renin / N. Goormagh-tigh // Arch. Biol. – 1932. – Vol. 43. – P. 575–591.

  12. Goormaghtigh N. Sclerose vasculaire du rein apres denervation des sinus carotidience et section des nerfs depresseurs / N. Goormaghtigh // Compt. Rend. Soc. Biol. – 1931. – Vol. 106. – P. 1254–1257.

  13. Guilan R. A. The juxtaglomerular complex / R. A. Guilan, S. Zelman, F. J. Murphy // Arch. Pathol. – 1967. – Vol. 84 (6). – P. 598–600.

  14. Kurtz A. Renin release: sites, mechanisms and control / A. Kurtz // Ann. Rew. Physiol. – 2011. – Vol. 73. – P. 377–390.

  15. Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the exxraglomerular mesangium / L. Kurtz [et al.] // J. Am. Soc. Nephrol. – 2007. – Vol. 18. – P. 1103–1111.

  16. Marks L. S. Tigerstedt and the discowery of renin. A historical note / L. S. Marks, M. H. Maxwell // Hypertension. – 1979. – Vol. 1. – P. 384–388.

  17. Metaplasia of smoth muscle cells into juxtaglomerular cells in the juxtaglomerular apparatus, arteries and arterioles of the ischemic kidney / M. Cantin [et al.] // Am. J. Pathol. – 1977. – Vol. 87, № 3. – P. 581–592.

  18. Oberling C. R. L'existense d'une housse neuromusculaire au niveau des arteres glomerulaires de s'Homme / C. R. Oberling // Compt. Rend. Acad. Sci. – 1927. – Vol. 184. – P. 1200–1202.

  19. Peti-Peterdi J. Macula densa sensing and signaling mechanisms of rennin release / I. Peti-Peterdi, R. C. Harris // J. Am. Soc. Nephrol. – 2010. – Vol. 21 (7). – P. 1093–1096.

  20. Reeves G. Sensitivity of the renal macula densa to urinary sodium proc. / G. Reeves, S. C. Som-mers // Soc. Exp. Biol. Med. – 1965. – Vol. 120 (2). – P. 324–326.

  21. Renin cells are precursors, for multiple cell types that switch to the renin phenotype when homestasis is threatened / Sequeira Lopez M. L. [et al.] // Dev. cell. – 2004. – Vol. 6. – P. 719–728.

  22. Renin release / F. Schweda [et al.] // Physiology. – 2007. – Vol. 22. – P. 310–319.

  23. Ruyter J. H. C. Uber einen Merkwurdigen abscnitt der Vas Afferentiv in der Mauseniere / J. H. C. Ruyter // Ztschr Mikrosk Anal Forsch. – 1925. – Vol. 2. – P. 242–248.

  24. Sequeira Lopez M. L. Novel mechanisms for the control of renin synthesis and release / Sequeira Lopez M. L., R. A. Gomez // Curr. Hypertens Rep. – 2010. – Vol. 12 (1). – P. 26–32.

  25. Succinate receptor (GPR 91) activation in macula densa cells causes renin release / S. L. Vargas [et al.] // J. Am. Soc. Nephrol. – 2009. – Vol. 20. –P. 1002–1011.

  26. Turau K. Renal blood fiow and dynamics of glomerular filtration: Evolution of a concept from Carl Ludwig to the present day / K. Turau, J. M. Davis, D. A. Häberle // Renal Physiology. People and Jdeas / Carl W. Gottschalk, Robert W. Berliner, Gerhard H. Giebish (eds.). – Bethesda, MD : American Physiological Society, 1987. – P. 31–61.

  27. Zimermann K. W. Uber den Bau des Glomerulus der menschlichen / K. W. Zimermann // Niere Z. Mikr. Anat. Forsch. – 1929. – Vol. 19. – P. 520–552.

  28. Zimermann K. W. Uber der Bau des Glomerulus der Saugerniere: Weittere Mitteilunger / K. W. Zimermann // Niere Z. Mikr. Anat. Forsch. – 1933. – Vol. 32. – P. 176–278.