«Ульяновский медико-биологический журнал»

REVIEWS

Download article

DOI 10.34014/2227-1848-2026-1-6-17

CIRCADIAN RHYTHM DYSREGULATION AND NEURODEGENERATION: A CONTEMPORARY REVIEW

 D.S. Gromova

 Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia

 

The aim of the study is to analyze current data on the mechanisms underlying specific neurodegenerative pathologies in the context of circadian rhythm dysregulation.

Materials and Methods. A literature search was conducted using the PubMed, CyberLeninka, Google Scholar, and RSCI (Russian Science Citation Index) databases. The search period spanned from 2015 to 2024.

Results. The incidence of sleep-wake cycle disorders in patients with neurodegenerative diseases is several times higher compared to those with other chronic pathologies.

The mechanism underlying the onset of sleep-wake dysregulation in Parkinson's disease is associated with many factors: damage to structures within the brain's photoperiodic system, dysregulation of the orexinergic system, pathological impulses from the basal ganglia, and even desynchronization of the molecular clock.

Patients with Alzheimer's disease demonstrate desynchronization in various physiological and behavioral responses. These patients exhibit a disrupted melatonin secretion pattern and reduced melatonin receptor levels in the suprachiasmatic nuclei of the hypothalamus.

Circadian dysfunction in Huntington's disease is associated with pathology of the hypothalamus, where both the suprachiasmatic nuclei and orexin neurons are located. However, there is evidence of involvement of brainstem neurons, which also explains the dysfunction of the noradrenergic system in regulating wakefulness.

Conclusion. Circadian rhythm dysregulation is observed in mane neurodegenerative diseases. However, for the most part, these dysfunctions require further investigation to improve therapeutic efficacy and patients' quality of life.

Key words: circadian system, neurodegeneration, Alzheimer's disease, Parkinson's disease, Huntington's disease.

 

Conflict of interest. The author declares no conflict of interest.

 

References

  1. Papalambros N.A. Acoustic enhancement of sleep slow oscillations in mild cognitive impairment. Ann Clin Transl Neurol. 2019; 7: 1191–1201. DOI: 10.1002/acn3.796. 

  2. Semenova N.V., Madaeva I.M., Kolesnikova L.I. Gen Clock, melatonin i tsikl “son – bodrstvovanie” [The Clock gene, melatonin, and the sleep-wake cycle]. Genetika. 2021; 57 (3): 247–254 (in Russian).

  3. Herring W.J. Polysomnographic assessment of suvorexant in patients with probable Alzheimer’s disease dementia and insomnia: a randomized trial. Alzheimer’s Dement. 2020; 16 (3): 541–551. DOI: 10.1002/alz.12035. 

  4. Cronin P. Circadian alterations during early stages of Alzheimer’s disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimers Dement. 2017; 13: 689–700.

  5. Pini L. Aberrant brain network connectivity in presymptomatic and manifest Huntington’s disease: a systematic review. Hum Brain Mapp. 2020; 41 (1): 256–269. DOI: 10.1002/hbm.24790.

  6. Mazurov N.A., Kicherova O.A., Verbakh T.E., Reykhert L.I., Doyan Yu.I., Saltanova V.A. Vklad tsirkadnykh ritmov v razvitiye nevrologicheskikh narusheniy posle dlitel'nogo anesteziologicheskogo obespecheniya [Contribution of circadian rhythms to the development of neurological disorders after prolonged anesthesia]. Klinicheskaya praktika. 2024; 15 (2): 59–64 (in Russian).

  7. Lyashenko E.A., Levin O.S., Poluektov M.G. Primeneniye melatonina dlya korrektsii rasstroystv povedeniya v faze sna s bystrymi dvizheniyami glaz pri bolezni Parkinsona [Melatonin in correction of REM-sleep behavior disorders in Parkinson’s disease]. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2015; 115 (6–2): 40–43 (in Russian).

  8. Grippo R.M., Guler A.D. Dopamine signaling in circadian photoentrainment: consequences of desynchrony. Yale J. Biol. Med. 2019; 92: 271–281.

  9. Arushanyan E.B. Khronopatologiya bolezni parkinsona i rol' melatonina v yeyё proiskhozhdenii [Chronopathology of Parkinson's disease and role of melatonin in its origin]. Meditsinskiy Vestnik Severnogo Kavkaza. 2016; 11 (3): 478–483 (in Russian).

  10. Wang H.B., Loh D.H., Whittaker D.S., Cutler T., Howland D., Colwell C.S. Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. eNeuro. 2018; 5 (1). DOI: 10.1523/ENEURO.0431-17.2017

  11. Leng Y., Musiek E. S., Hu K., Cappuccio F. P., Yaffe K. Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol. 2019; 18: 307–318.

  12. Malhotra R.K. Neurodegenerative disorders and sleep. Sleep Med Clin. 2018; 13 (1): 63–70.

  13. Arnao V., Cinturino A., Mastrilli S. Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting. BMC Neurol. 2020; 152. DOI: https://doi.org/10.1186/s12883-020-01722-3.

  14. Nassan M., Videnovic A. Circadian rhythms in neurodegenerative disorders. Nat Rev Neurol. 2022; 8 (1): 7–24. DOI: 10.1038/s41582-021-00577-7.

  15. Hulme B. Epigenetic regulation of BMAL1 with sleep disturbances and Alzheimer’s disease. Alzheimers Dis. 2020; 77: 1783–1792.

  16. Liu Y., Niu L., Liu X. et al. Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation. Neurosci. Bull. 2021; 37: 1010–1024. DOI: https://doi.org/10.1007/s12264-021-00711-x.

  17. Yamshchikova N.G., Stavrovskaya A.V., Illarioshkin S.N. Nekotor·yye aspekty razvitiya neyrodegenerativnykh zabolevaniy [Some aspects of the development of neurodegenerative diseases]. Asimmetriya. 2018; 12 (4): 631–645 (in Russian).

  18. Nodel' M.R. Sovremenn·yye diagnosticheskiye kriterii bolezni Parkinsona [Diagnostic criteria for Parkinson's disease]. Rossiyskiy zhurnal geriatricheskoy meditsiny. 2021; 1(5): 92–96. DOI: 10.37586/2686-8636-1-2021-92-96 (in Russian).

  19. Voronkov D.N., Sal'kov V.N., Anufriev P.L., Khudoerkov R.M. Tel'tsa Levi pri bolezni Parkinsona (gistologicheskoye, immunogistokhimicheskoye i interferometricheskoye issledovaniye) [Lewy bodies in Parkinson’s disease: histological, immunohistochemical, and interferometric examinations]. Arkhiv patologii. 2018; 80 (4): 9–13 (in Russian).

  20. Jost W.H. Autonomic Dysfunction in Parkinson's Disease: Cardiovascular Symptoms, Thermoregulation, and Urogenital Symptoms. Int Rev Neurobiol. 2017; 134: 771–785.

  21. Fifel K., Videnovic A. Circadian alterations in patients with neurodegenerative diseases: neuropathological basis of underlying network mechanisms. Neurobiol Dis. 2020; 144: 105–129.

  22. Vallee A., Lecarpentier Y., Guillevin R., Vallee J.N. Circadian rhythms, neuroinflammation and oxidative stress in the story of Parkinson’s disease. Cells. 2020; 9: 314.

  23. Tsvetkova E.S., Romantsova T.I., Runova G.E., Belyaev N.S., Gol'dshmid A.E. Vliyaniye smennogo grafika raboty na pokazateli metabolicheskogo zdorov'ya [The influence of shift work on metabolic health]. Ozhireniye i metabolizm. 2019; 16 (3): 11–19. DOI: https://doi.org/10.14341/omet10015 (in Russian).

  24. Voysey Z., Fazal S.V., Lazar A.S., Barker. R.A. The sleep and circadian problems of Huntington’s disease: when, why and their importanc. J Neurol. 2021; 268 (6): 2275–2283. DOI: 10.1007/s00415-020-10334-3.

  25. Dibner C., Schibler U. Circadian timing of metabolism in animal models and humans. J Intern Med. 2015; 5: 513–527. DOI: https://doi.org/10.1111/joim.12347.

  26. Saenz-Farret M. Neuropsychiatric symptoms and premanifest Huntington’s disease. Mov. Disord. 2017; 32 (3): 481. DOI: 10.1016/j.parkreldis.2016.02.008.

  27. Videnovic A., Golombek D. Circadian Dysregulation in Parkinson's Disease. Neurobiol Sleep Circadian Rhythms. 2017; 2: 53–58.

  28. Shen Y., Lv Qk., Xie Wy. Circadian disruption and sleep disorders in neurodegeneration. Transl Neurodegener. 2023; 12 (1): DOI: https://doi.org/10.1186/s40035-023-00340-6.

  29. Diago E.B. Circadian rhythm, cognition, and mood disorders in Huntington’s disease. J. Huntingt. Dis. 2018; 7: 193–198.

  30. Niu L., Zhang F., Xu X., Yang Y., Li S., Liu H., Le W. Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology. Brain Pathol. 2022; 32 (3): e13028. DOI: 10.1111/bpa.13028.

  31. Pini L. Aberrant brain network connectivity in presymptomatic and manifest Huntington’s disease: a systematic review. Hum Brain Mapp. 2020; 1: 256–269.

  32. Abulafia C. Relationship between cognitive and sleep-wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease. Front. Aging Neurosci. 2017; 9: 93.

  33. Ribas-Latre A., Eckel-Mahan K. Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health. Mol Metab. 2016; 5 (3): 133–152. DOI: https://doi.org/10.1016/j.molmet.2015.12.006.

  34. Soltani S. Sleep-Wake Cycle in Young and Older Mice. Front Syst Neurosci. 2019; 13: 51.

  35. Babkina O.V., Poluektov M.G., Levin O.S. Narusheniye mekhanizmov tsirkadiannoy regulyatsii pri vozrastzavisimykh neyrodegenerativnykh zabolevaniyakh [Disruption of the mechanisms of circadian regulation in age-depemdent neurodegenerative diseases]. Nevrologiya i psikhiatriya. Spetsvypusk «Son i yego rasstroystva – 5». 2017: 114–122 (in Russian).

  36. Yakovleva O.V., Poluektov M.G., Levin O.S., Lyashenko E.A. Narusheniya sna i bodrstvovaniya pri neyrodegenerativnykh zabolevaniyakh [Sleep and wakefulness disorders in neurodegenerative diseases]. Zhurnal nevrologii i psikhiatrii. 2018; 4: 83–91 (in Russian).

  37. Wang C., Holtzman D.M. Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors. Neuropsychopharmacology. 2020; 45 (1): 104–120. DOI: 10.1038/s41386-019-0478-5.

  38. Rasmussen M.K., Mestre H., Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018; 17: 1016–1024.

  39. Fultz N.E. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019; 366: 628–631.

  40. Zhang Y. Sleep in Huntington’s disease: a systematic review and meta-analysis of polysomongraphic findings. Sleep. 2019; 42 (10): zsz154. DOI: 10.1093/sleep/zsz154.

  41. Wang J.L., Lim A.S., Chiang W.Y., Hsieh W.H., Lo M.T et al. Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans. Annals of neurology. 2015; 2: 317–322. 

  42. Manni R. Evening melatonin timing secretion in real life conditions in patients with Alzheimer disease of mild to moderate severity. Sleep Med. 2019; 63: 122–126.

  43. Titova N., Chaudhuri K.R. Non-motor Parkinson disease: new concepts and personalised management. Med. J. Aust. 2018; 208: 404–409.

  44. Fifel K. Alterations of the circadian system in Parkinson’s disease patients. Mov. Disord. 2017; 32 (5): 682–692.

  45. Herzog-Krzywoszanska R.., Krzywoszanski L. Sleep disorders in Huntington’s disease. Front. Psychiatry. 2019; 10: 221. DOI: 10.3389/fpsyt.2019.00221.

  46. Peter-Derex L., Yammine P., Bastuji H., Croisile B. Sleep and Alzheimer’s disease. Sleep Med Rev. 2015; 19: 29–38. DOI: 10.1016/j.smrv.2014.03.007

  47. Munoz-Manchado A.B. Chronic and progressive Parkinson's disease MPTP model in adult and aged mice. J Neurochem. 2016; 136 (2): 373–387.

  48. Ono D., Honma K. I., Honma, S. GABAergic mechanisms in the suprachiasmatic nucleus that influence circadian rhythm. J. Neurochem. 2021; 157: 31–41

  49. Baker E. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS One. 2019; 14 (7):e0218111. DOI: 10.1371/journal.pone.0218111.

  50. Leng Y. Association of circadian abnormalities in older adults with an increased risk of developing parkinson disease. JAMA Neurol. 2020; 77: 1270–1278.

  51. De Pablo-Fernández E., Courtney R., Warner T.T., Holton J.L. A Histologic Study of the Circadian System in Parkinson Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy. JAMA Neurol. 2018; 8: 1008–1012. DOI: 10.1001/jamaneurol.2018.0640.

Received January 15, 2025; accepted June 16, 2025.

 

Information about the author

Gromova Dar'ya Sergeyevna, Senior Lecturer, Chair of General and Molecular Biology, Chair of Physiology, Samara State Medical University, Ministry of Health of the Russian Federation. 443099, Russia, Samara, Chapayevskaya St., 89; e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра., ORCID ID: https://orcid.org/0000-0003-0650-0252

 

For citation

Gromova D.S. Narusheniya tsirkadiannogo ritma i neyrodegeneratsiya: sovremennyy obzor problem [Circadian rhythm dysregulation and neurodegeneration: A contemporary review]. Ul'yanovskiy mediko-biologicheskiy zhurnal. 2026; 1: 6–17. DOI: 10.34014/2227-1848-2026-1-6-17 (in Russian).

 

Скачать статью

УДК 612

DOI 10.34014/2227-1848-2026-1-6-17

НАРУШЕНИЯ ЦИРКАДИАННОГО РИТМА И НЕЙРОДЕГЕНЕРАЦИЯ: СОВРЕМЕННЫЙ ОБЗОР ПРОБЛЕМЫ

 Д.С. Громова

ФГБОУ ВО «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации, г. Самара, Россия

 

Цель работы - проанализировать современные данные, освещающие механизмы развития отдельных нейродегенеративных патологий при нарушениях циркадианного ритма.

Материалы и методы. Поиск литературных источников проводился по базам данных PubMed, CyberLeninka, Google Scholar и РИНЦ. Временной горизонт поиска охватывал 2015–2024 гг.

Результаты. Нарушения цикла «сон – бодрствование» у пациентов с нейродегенеративными заболеваниями встречаются в несколько раз чаще, чем при других хронических заболеваниях.

Механизм возникновения нарушений сна и бодрствования при болезни Паркинсона связан со множеством факторов: повреждением структур, входящих в фотопериодическую систему мозга, недостаточностью функции орексинергической системы, патологической импульсацией от базальных ганглиев и даже десинхронозом на молекулярном уровне.

Пациенты с болезнью Альцгеймера демонстрируют десинхроноз в различных проявлениях физиологических и поведенческих реакций. У них нарушен паттерн секреции мелатонина, снижено содержание рецепторов к нему в супрахиазматических ядрах гипоталамуса.

Циркадианная дисфункция при болезни Гентингтона связана с патологией гипоталамуса, где расположены как супрахиазматические ядра, так и нейроны орексина. Однако имеются данные и о вовлечении нейронов ствола мозга, что также объясняет дисфункцию норадренергической системы при регуляции бодрствования.

Выводы. Нарушения циркадианного ритма наблюдаются при многих нейродегенеративных заболеваниях, однако в большинстве своем они требуют более пристального изучения, что может способствовать повышению эффективности терапии и улучшению качества жизни пациентов.

Ключевые слова: циркадианная система, нейродегенерация, болезнь Альцгеймера, болезнь Паркинсона, болезнь Гентингтона.

 

Конфликт интересов. Автор заявляет об отсутствии конфликта интересов.

 

Литература

  1. Papalambros N.A. Acoustic enhancement of sleep slow oscillations in mild cognitive impairment. Ann Clin Transl Neurol. 2019; 7: 1191–1201. DOI: 10.1002/acn3.796. 

  2. Семёнова Н.В., Мадаева И.М., Колесникова Л.И. Ген Clock, мелатонин и цикл «сон – бодрствование». Генетика. 2021; 57 (3): 247–254.

  3. Herring W.J. Polysomnographic assessment of suvorexant in patients with probable Alzheimer’s disease dementia and insomnia: a randomized trial. Alzheimer’s Dement. 2020; 16 (3): 541–551. DOI: 10.1002/alz.12035. 

  4. Cronin P. Circadian alterations during early stages of Alzheimer’s disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimers Dement. 2017; 13: 689–700.

  5. Pini L. Aberrant brain network connectivity in presymptomatic and manifest Huntington’s disease: a systematic review. Hum Brain Mapp. 2020; 41 (1): 256–269. DOI: 10.1002/hbm.24790.

  6. Мазуров Н.А., Кичерова О.А., Вербах Т.Э., Рейхерт Л.И., Доян Ю.И., Салтанова В.А. Вклад циркадных ритмов в развитие неврологических нарушений после длительного анестезиологического обеспечения. Клиническая практика. 2024; 15 (2): 59–64.

  7. Ляшенко Е.А., Левин О.С., Полуэктов М.Г. Применение мелатонина для коррекции расстройств поведения в фазе сна с быстрыми движениями глаз при болезни Паркинсона. Журнал неврологии и психиатрии им. С.С. Корсакова. 2015; 115 (6–2): 40–43.

  8. Grippo R.M., Guler A.D. Dopamine signaling in circadian photoentrainment: consequences of desynchrony. Yale J. Biol. Med. 2019; 92: 271–281.

  9. Арушанян Э.Б. Хронопатология болезни паркинсона и роль мелатонина в ее происхождении. Медицинский Вестник Северного Кавказа. 2016; 11 (3): 478–483.

  10. Wang H.B., Loh D.H., Whittaker D.S., Cutler T., Howland D., Colwell C.S. Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. eNeuro. 2018; 5 (1). DOI: 10.1523/ENEURO.0431-17.2017

  11. Leng Y., Musiek E. S., Hu K., Cappuccio F. P., Yaffe K. Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol. 2019; 18: 307–318.

  12. Malhotra R.K. Neurodegenerative disorders and sleep. Sleep Med Clin. 2018; 13 (1): 63–70.

  13. Arnao V., Cinturino A., Mastrilli S. Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting. BMC Neurol. 2020; 152. DOI: https://doi.org/10.1186/s12883-020-01722-3.

  14. Nassan M., Videnovic A. Circadian rhythms in neurodegenerative disorders. Nat Rev Neurol. 2022; 8 (1): 7–24. DOI: 10.1038/s41582-021-00577-7.

  15. Hulme B. Epigenetic regulation of BMAL1 with sleep disturbances and Alzheimer’s disease. Alzheimers Dis. 2020; 77: 1783–1792.

  16. Liu Y., Niu L., Liu X. et al. Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation. Neurosci. Bull. 2021; 37: 1010–1024. DOI: https://doi.org/10.1007/s12264-021-00711-x.

  17. Ямщикова Н.Г., Ставровская А.В., Иллариошкин С.Н. Некоторые аспекты развития нейродегенеративных заболеваний. Асимметрия. 2018; 12 (4): 631–645.

  18. Нодель М.Р. Современные диагностические критерии болезни Паркинсона. Российский журнал гериатрической медицины. 2021; 1(5): 92–96. DOI: 10.37586/2686-8636-1-2021-92-96.

  19. Воронков Д.Н., Сальков В.Н., Ануфриев П.Л., Худоерков Р.М. Тельца Леви при болезни Паркинсона (гистологическое, иммуногистохимическое и интерферометрическое исследование). Архив патологии. 2018; 80 (4): 9–13.

  20. Jost W.H. Autonomic Dysfunction in Parkinson's Disease: Cardiovascular Symptoms, Thermoregulation, and Urogenital Symptoms. Int Rev Neurobiol. 2017; 134: 771–785.

  21. Fifel K., Videnovic A. Circadian alterations in patients with neurodegenerative diseases: neuropathological basis of underlying network mechanisms. Neurobiol Dis. 2020; 144: 105–129.

  22. Vallee A., Lecarpentier Y., Guillevin R., Vallee J.N. Circadian rhythms, neuroinflammation and oxidative stress in the story of Parkinson’s disease. Cells. 2020; 9: 314.

  23. Цветкова Е.С., Романцова Т.И., Рунова Г.Е., Беляев Н.С., Гольдшмид А.Е. Влияние сменного графика работы на показатели метаболического здоровья. Ожирение и метаболизм. 2019; 16 (3): 11–19. DOI: https://doi.org/10.14341/omet10015.

  24. Voysey Z., Fazal S.V., Lazar A.S., Barker. R.A. The sleep and circadian problems of Huntington’s disease: when, why and their importanc. J Neurol. 2021; 268 (6): 2275–2283. DOI: 10.1007/s00415-020-10334-3.

  25. Dibner C., Schibler U. Circadian timing of metabolism in animal models and humans. J Intern Med. 2015; 5: 513–527. DOI: https://doi.org/10.1111/joim.12347.

  26. Saenz-Farret M. Neuropsychiatric symptoms and premanifest Huntington’s disease. Mov. Disord. 2017; 32 (3): 481. DOI: 10.1016/j.parkreldis.2016.02.008.

  27. Videnovic A., Golombek D. Circadian Dysregulation in Parkinson's Disease. Neurobiol Sleep Circadian Rhythms. 2017; 2: 53–58.

  28. Shen Y., Lv Qk., Xie Wy. Circadian disruption and sleep disorders in neurodegeneration. Transl Neurodegener. 2023; 12 (1): DOI: https://doi.org/10.1186/s40035-023-00340-6.

  29. Diago E.B. Circadian rhythm, cognition, and mood disorders in Huntington’s disease. J. Huntingt. Dis. 2018; 7: 193–198.

  30. Niu L., Zhang F., Xu X., Yang Y., Li S., Liu H., Le W. Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology. Brain Pathol. 2022; 32 (3): e13028. DOI: 10.1111/bpa.13028.

  31. Pini L. Aberrant brain network connectivity in presymptomatic and manifest Huntington’s disease: a systematic review. Hum Brain Mapp. 2020; 1: 256–269.

  32. Abulafia C. Relationship between cognitive and sleep-wake variables in asymptomatic offspring of patients with late-onset Alzheimer’s disease. Front. Aging Neurosci. 2017; 9: 93.

  33. Ribas-Latre A., Eckel-Mahan K. Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health. Mol Metab. 2016; 5 (3): 133–152. DOI: https://doi.org/10.1016/j.molmet.2015.12.006.

  34. Soltani S. Sleep-Wake Cycle in Young and Older Mice. Front Syst Neurosci. 2019; 13: 51.

  35. Бабкина О.В., Полуэктов М.Г., Левин О.С. Нарушение механизмов циркадианной регуляции при возрастзависимых нейродегенеративных заболеваниях. Неврология и психиатрия. Спецвыпуск «Сон и его расстройства – 5». 2017: 114–122.

  36. Яковлева О.В., Полуэктов М.Г., Левин О.С., Ляшенко Е.А. Нарушения сна и бодрствования при нейродегенеративных заболеваниях. Журнал неврологии и психиатрии. 2018; 4: 83–91.

  37. Wang C., Holtzman D.M. Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors. Neuropsychopharmacology. 2020; 45 (1): 104–120. DOI: 10.1038/s41386-019-0478-5.

  38. Rasmussen M.K., Mestre H., Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018; 17: 1016–1024.

  39. Fultz N.E. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019; 366: 628–631.

  40. Zhang Y. Sleep in Huntington’s disease: a systematic review and meta-analysis of polysomongraphic findings. Sleep. 2019; 42 (10): zsz154. DOI: 10.1093/sleep/zsz154.

  41. Wang J.L., Lim A.S., Chiang W.Y., Hsieh W.H., Lo M.T et al. Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans. Annals of neurology. 2015; 2: 317–322. 

  42. Manni R. Evening melatonin timing secretion in real life conditions in patients with Alzheimer disease of mild to moderate severity. Sleep Med. 2019; 63: 122–126.

  43. Titova N., Chaudhuri K.R. Non-motor Parkinson disease: new concepts and personalised management. Med. J. Aust. 2018; 208: 404–409.

  44. Fifel K. Alterations of the circadian system in Parkinson’s disease patients. Mov. Disord. 2017; 32 (5): 682–692.

  45. Herzog-Krzywoszanska R.., Krzywoszanski L. Sleep disorders in Huntington’s disease. Front. Psychiatry. 2019; 10: 221. DOI: 10.3389/fpsyt.2019.00221.

  46. Peter-Derex L., Yammine P., Bastuji H., Croisile B. Sleep and Alzheimer’s disease. Sleep Med Rev. 2015; 19: 29–38. DOI: 10.1016/j.smrv.2014.03.007

  47. Munoz-Manchado A.B. Chronic and progressive Parkinson's disease MPTP model in adult and aged mice. J Neurochem. 2016; 136 (2): 373–387.

  48. Ono D., Honma K. I., Honma, S. GABAergic mechanisms in the suprachiasmatic nucleus that influence circadian rhythm. J. Neurochem. 2021; 157: 31–41

  49. Baker E. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS One. 2019; 14 (7):e0218111. DOI: 10.1371/journal.pone.0218111.

  50. Leng Y. Association of circadian abnormalities in older adults with an increased risk of developing parkinson disease. JAMA Neurol. 2020; 77: 1270–1278.

  51. De Pablo-Fernández E., Courtney R., Warner T.T., Holton J.L. A Histologic Study of the Circadian System in Parkinson Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy. JAMA Neurol. 2018; 8: 1008–1012. DOI: 10.1001/jamaneurol.2018.0640.

Поступила в редакцию 15.01.2025; принята 16.06.2025.

 

Автор

Громова Дарья Сергеевна – старший преподаватель кафедры общей и молекулярной биологии, старший преподаватель кафедры физиологии, ФГБОУ ВО «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации. 443099, Россия, г. Самара, ул. Чапаевская, 89; e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра., ORCID ID: https://orcid.org/0000-0003-0650-0252